human PDCD1 Adenovirus

Name 
Ad-h-PDCD1
Cat No 
ADV-218432
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human PDCD1.

ADV-218432
Ad-h-PDCD1

Ready-to-use Adenovirus expressing Human PDCD1 (programmed cell death 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CD antigen CD279; CD279; hPD-1; hPD-l; hSLE1; PD1; PD-1; programmed cell death 1 protein; programmed cell death protein 1; protein PD-1; SLEB2; systemic lupus erythematosus susceptibility 2
Description (eCommerce)
PD-1 is a cell surface membrane protein of the immunoglobulin superfamily. It is an inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. PD-1 delivers inhibitory signals upon binding to ligands CD274/PD-L1 and CD273/PD-L2. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15116].
Description (Vector)
PDCD1 encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.
Gene ID
5133
Gene Name (eCommerce)
programmed cell death 1
Gene Name (Vector)
programmed cell death 1
Gene Symbol
PDCD1
HGNC ID
HGNC:8760
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
867
Protein Name (eCommerce)
Programmed cell death protein 1
RefSeq ID
NM_005018
RefSeq Synonyms
NM_005018, BC074740,
Research Areas
Apoptosis,Immunology,Signal Transduction,T-cell Receptor Signaling
Research Areas (Faceted)
signal_transduction,cell_biology,immunology,signal_transduction
Species
human
Target Sentence
PD-1 is a cell surface membrane protein of the immunoglobulin superfamily. It is an inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. PD-1 delivers inhibitory signals upon binding to ligands CD274/PD-L1 and CD273/PD-L2. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15116].
UniGene ID
Hs.158297
UniProt ID (eCommerce)
Q15116

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.