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human MTHFD1 Adenovirus

Name 
Ad-h-MTHFD1
Cat No 
ADV-215989
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human MTHFD1.

ADV-215989
Ad-h-MTHFD1

Ready-to-use Adenovirus expressing Human MTHFD1 (methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolate cyclohydrolase, 10-formyltetrahydrofolate synthetase; C-1-tetrahydrofolate synthase, cytoplasmic; C1-THF synthase; CIMAH; cytoplasmic C-1-tetrahydrofolate synthase; epididymis secretory sperm binding protein; Formyltetrahydrofolate synthetase; Methylenetetrahydrofolate dehydrogenase; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase; MTHFC; MTHFD
Description (eCommerce)
Methylenetetrahydrofolate dehydrogenase (MTHFD1) possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain [taken from NCBI Entrez Gene (Gene ID: 4522)].
Description (Vector)
MTHFD1 encodes a protein that possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain.
Gene ID
4522
Gene Name (eCommerce)
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
Gene Name (Vector)
methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
Gene Symbol
MTHFD1
HGNC ID
HGNC:7432
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2808
ORF Size (bp)
2808 bp
Protein Name (eCommerce)
C-1-tetrahydrofolate synthase, cytoplasmic
RefSeq ID
NM_005956
RefSeq Synonyms
NM_005956, BC050420, BC009806,
Research Areas
Cancer,Metabolism/Metabolic Process,Mitochondrion
Research Areas (Faceted)
cancer,metabolism,cell_biology
Species
human
Target Sentence
Methylenetetrahydrofolate dehydrogenase (MTHFD1) possesses three distinct enzymatic activities, 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase. Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for methionine, thymidylate, and de novo purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain [taken from NCBI Entrez Gene (Gene ID: 4522)].
UniGene ID
Hs.652308
UniProt ID (eCommerce)
P11586

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.