human MGRN1 Adenovirus

Name 
Ad-h-MGRN1
Cat No 
ADV-215430
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human MGRN1.

ADV-215430
Ad-h-MGRN1

Ready-to-use Adenovirus expressing Human MGRN1 (mahogunin ring finger 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
E3 ubiquitin-protein ligase MGRN1; mahogunin ring finger 1, E3 ubiquitin protein ligase; mahogunin RING finger protein 1; probable E3 ubiquitin-protein ligase MGRN1; RING finger protein 156; RING-type E3 ubiquitin transferase MGRN1; RNF156
Description (eCommerce)
MGRN1 (mahogunin RING finger protein 1) is an E3 ubiquitin-protein ligase that mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. MGRN1 plays a role in the regulation of endosome-to-lysosome trafficking. It impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production but does not promote MC1R ubiquitination [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O60291].
Description (Vector)
Mahogunin (MGRN1) is a C3HC4 RING-containing protein with E3 ubiquitin ligase activity in vitro.(supplied by OMIM, Apr 2004)
Gene ID
23295
Gene Name (eCommerce)
mahogunin ring finger 1
Gene Name (Vector)
mahogunin ring finger 1
Gene Symbol
MGRN1
HGNC ID
HGNC:20254
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1731
ORF Size (bp)
1731 bp
Protein Name (eCommerce)
E3 ubiquitin-protein ligase MGRN1
RefSeq ID
NM_015246
RefSeq Synonyms
NM_015246, NM_001142291, NM_001142290, NM_001142289, BC050389,
Research Areas
Antigen Processing and Presentation,Immunology,Lysosomal Transport,Signal Transduction,Transport,Ubiquitination,Zinc-finger
Research Areas (Faceted)
cell_biology,immunology,signal_transduction
Species
human
Target Sentence
MGRN1 (mahogunin RING finger protein 1) is an E3 ubiquitin-protein ligase that mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. MGRN1 plays a role in the regulation of endosome-to-lysosome trafficking. It impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production but does not promote MC1R ubiquitination [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O60291].
UniGene ID
Hs.526494
UniProt ID (eCommerce)
O60291

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.