human MDM4 Adenovirus
This is an Adenovirus expressing Human MDM4.
ADV-215221
Ad-h-MDM4
Ready-to-use Adenovirus expressing Human MDM4 (MDM4, p53 regulator). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Double minute 4 protein; double minute 4, human homolog of; HDMX; mdm2-like p53-binding protein; Mdm4 p53 binding protein homolog; MDM4 protein variant G; MDM4 protein variant Y; MDM4-related protein 1; MDMX; MRP1; p53-binding protein; p53-binding protein Mdm4; protein Mdm4; protein Mdmx
Description (eCommerce)
HdmX/MDM4 is a RING-finger domain containing protein that interacts with p53. HdmX/MDM4 may influence p53 stability through an interaction with the structurally similar MDM2, an ubiquitin-ligase that targets p53 for proteasomal degradation. HdmX/MDM4 may influence p53 by directly attenuating p53 transcriptional activity.
Description (Vector)
MDM4 encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Gene ID
4194
Gene Name (eCommerce)
MDM4, p53 regulator
Gene Name (Vector)
MDM4, p53 regulator
Gene Symbol
MDM4
HGNC ID
HGNC:6974
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1473
ORF Size (bp)
1473 bp
Protein Name (eCommerce)
Protein Mdm4
RefSeq ID
NM_002393
RefSeq Synonyms
NM_002393, NM_001278519, NM_001278518, NM_001278517, NM_001278516, NM_001204172, NM_001204171, BC105106, BC067299,
Research Areas
Apoptosis,Cancer,Cell Cycle,Glioma,Hypoxia,MicroRNAs in Cancer,Neurobiology,p53 Signaling,Phospho-specific,Signal Transduction,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
HdmX/MDM4 is a RING-finger domain containing protein that interacts with p53. HdmX/MDM4 may influence p53 stability through an interaction with the structurally similar MDM2, an ubiquitin-ligase that targets p53 for proteasomal degradation. HdmX/MDM4 may influence p53 by directly attenuating p53 transcriptional activity.
UniGene ID
Hs.497492
UniProt ID (eCommerce)
O15151
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.