human MARCH1 Adenovirus
This is an Adenovirus expressing Human MARCH1.
ADV-215013
Ad-h-MARCH1
Ready-to-use Adenovirus expressing Human MARCH1 (membrane associated ring-CH-type finger 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
MARCH-I; RNF171
Description (Vector)
MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 (PubMed 14722266); Thibodeau et al., 2008 (PubMed 18389477); De Gassart et al., 2008 (PubMed 18305173)).(supplied by OMIM, Mar 2010)
Gene ID
55016
Gene Name (Vector)
membrane associated ring-CH-type finger 1
Gene Symbol
1-Mar
HGNC ID
HGNC:26077
ORF Size (aa)
819
ORF Size (bp)
819 bp
RefSeq ID
NM_017923
RefSeq Synonyms
NM_017923, NM_001166373, BC153124, BC148531,
Species
human
UniGene ID
Hs.696248
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.