human TGIF1 Adenovirus

Name 
Ad-h-TGIF1
Cat No 
ADV-214075
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human TGIF1.

ADV-214075
Ad-h-TGIF1

Ready-to-use Adenovirus expressing Human TGIF1 (TGFB induced factor homeobox 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
HPE4; TGIF
Description (Vector)
TGIF1 is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and eight variants, encoding four distinct isoforms, are described.
Gene ID
7050
Gene Name (Vector)
TGFB induced factor homeobox 1
Gene Symbol
TGIF1
HGNC ID
HGNC:11776
ORF Size (aa)
1206
ORF Size (bp)
1206 bp
RefSeq ID
NM_003244
RefSeq Synonyms
NM_174886, NM_173211, NM_173210, NM_173209, NM_173208, NM_173207, NM_170695, NM_003244, NM_001278686, NM_001278684, NM_001278682, BC031268, BC000814,
Species
human
UniGene ID
Hs.373550

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.