human KIF7 Adenovirus

Name
Ad-h-KIF7

Cat No
ADV-213113

Availability
4-5 weeks

This is an Adenovirus expressing Human DGKA.

ADV-213113

Ad-h-KIF7

Ready-to-use Adenovirus expressing Human KIF7 (kinesin family member 7). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

ACLS; AGBK; EQYK340; HLS2; JBTS12; kinesin-like protein KIF7; UNQ340

Description (eCommerce)

KIF7 (kinesin family member 7) is the mammalian homolog of the zebrafish Cos2 protein. KIF7 has been shown to play an essential role in Hedgehog (Hh) signaling at the tip of cilia.

Description (Vector)

KIF7 encodes a cilia-associated protein belonging to the kinesin family. This protein plays a role in the sonic hedgehog (SHH) signaling pathway through the regulation of GLI transcription factors. It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand, and as a positive regulator by preventing the processing of GLI3 into its repressor form. Mutations in this gene have been associated with various ciliopathies.

Gene ID

374654

Gene Name (eCommerce)

kinesin family member 7

Gene Name (Vector)

kinesin family member 7

Gene Symbol

KIF7

HGNC ID

HGNC:30497

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

2490

ORF Size (bp)

2490 bp

Protein Name (eCommerce)

Kinesin-like protein KIF7

RefSeq ID

NM_198525

RefSeq Synonyms

NM_198525, BC143461, BC112273, BC112271, BC104044,

Research Areas

Hedgehog Signaling,Neurobiology,Signal Transduction,Transport

Research Areas (Faceted)

cell_biology,neurobiology,signal_transduction

Species

human

Target Sentence

KIF7 (kinesin family member 7) is the mammalian homolog of the zebrafish Cos2 protein. KIF7 has been shown to play an essential role in Hedgehog (Hh) signaling at the tip of cilia.

UniGene ID

Hs.513134

UniProt ID (eCommerce)

Q2M1P5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.