human ITGA6 Adenovirus
This is an Adenovirus expressing Human ITGA6.
ADV-212483
Ad-h-ITGA6
Ready-to-use Adenovirus expressing Human ITGA6 (integrin subunit alpha 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD antigen CD49f; CD49 antigen-like family member F; CD49f; integrin alpha-6; integrin alpha6B; integrin, alpha 6; ITGA6B; VLA-6
Description (eCommerce)
Integrin alpha 6 forms heterodimers with integrin beta 1 or beta 4 and functions as a receptor for the extracellular matrix protein, laminin. Integrin alpha 6 is encoded by the ITGA6 gene. Defects in ITGA6 are a cause of epidermolysis bullosa letalis with pyloric atresia (EB-PA) [MIM:226730]; also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P23229].
Description (Vector)
The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
3655
Gene Name (eCommerce)
integrin subunit alpha 6
Gene Name (Vector)
integrin subunit alpha 6
Gene Symbol
ITGA6
HGNC ID
HGNC:6142
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3222
ORF Size (bp)
3222 bp
Protein Name (eCommerce)
Integrin alpha-6
RefSeq ID
NM_000210
RefSeq Synonyms
NM_001316306, NM_001079818, NM_000210, BC136456, BC136455,
Research Areas
Apoptosis,Cancer,Cardiology,Cardiomyopathy,Cardiovascular,Cytoskeleton,Immunology,Lung Cancer,PI3K/Akt Signaling,Signal Transduction
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,immunology,signal_transduction
Species
human
Target Sentence
Integrin alpha 6 forms heterodimers with integrin beta 1 or beta 4 and functions as a receptor for the extracellular matrix protein, laminin. Integrin alpha 6 is encoded by the ITGA6 gene. Defects in ITGA6 are a cause of epidermolysis bullosa letalis with pyloric atresia (EB-PA) [MIM:226730]; also known as junctional epidermolysis bullosa with pyloric atresia (PA-JEB) or aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P23229].
UniGene ID
Hs.133397
UniProt ID (eCommerce)
P23229
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.