human HLA-F Adenovirus

Name
Ad-h-HLA-F

Cat No
ADV-211237

Availability
4-5 weeks

This is an Adenovirus expressing Human HLA-F.

ADV-211237

Ad-h-HLA-F

Ready-to-use Adenovirus expressing Human HLA-F (major histocompatibility complex, class I, F). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

CDA12; HLA-5.4; HLA-CDA12; HLAF

Description (Vector)

HLA-F belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. HLA-F exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain.

Gene ID

3134

Gene Name (Vector)

major histocompatibility complex, class I, F

Gene Symbol

HLA-F

HGNC ID

HGNC:4963

ORF Size (aa)

1041

ORF Size (bp)

1041 bp

RefSeq ID

NM_018950

RefSeq Synonyms

NM_018950, NM_001098479, NM_001098478, BC062991, BC009260,

Species

human

UniGene ID

Hs.519972

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.