human HLA-DOB Adenovirus

Name
Ad-h-HLA-DOB

Cat No
ADV-211215

Availability
4-5 weeks

This is an Adenovirus expressing Human HLA-DOB.

ADV-211215

Ad-h-HLA-DOB

Ready-to-use Adenovirus expressing Human HLA-DOB (major histocompatibility complex, class II, DO beta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

DOB

Description (Vector)

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.

Gene ID

3112

Gene Name (Vector)

major histocompatibility complex, class II, DO beta

Gene Symbol

HLA-DOB

HGNC ID

HGNC:4937

ORF Size (aa)

822

ORF Size (bp)

822 bp

RefSeq ID

NM_002120

RefSeq Synonyms

NM_002120, BC006097,

Species

human

UniGene ID

Hs.1802

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.