human HISPPD1 Adenovirus

Name 
Ad-h-HISPPD1
Cat No 
ADV-211048
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human HISPPD1.

ADV-211048
Ad-h-HISPPD1

Ready-to-use Adenovirus expressing Human PPIP5K2 (diphosphoinositol pentakisphosphate kinase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CFAP160; deafness, autosomal recessive 100; DFNB100; Diphosphoinositol pentakisphosphate kinase 2; HISPPD1; histidine acid phosphatase domain-containing protein 1; hsVIP2; inositol heptaphosphate kinase 2; inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2; insP6 and PP-IP5 kinase 2; IP7K2; VIP1 homolog 2; VIP2
Description (eCommerce)
PPIP5K2 is a bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. PPPIP5K2 phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, PPIP5K2 phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O43314].
Description (Vector)
Inositol phosphates (IPs) and diphosphoinositol phosphates (PP-IPs), also known as inositol pyrophosphates, act as cell signaling molecules. HISPPD1 has both IP6 kinase (EC 2.7.4.21) and PP-IP5 (also called IP7) kinase (EC 2.7.4.24) activities that produce the high-energy pyrophosphates PP-IP5 and PP2-IP4 (also called IP8), respectively (Fridy et al., 2007 (PubMed 17690096)).(supplied by OMIM, Mar 2008)
Gene ID
23262
Gene Name (eCommerce)
diphosphoinositol pentakisphosphate kinase 2
Gene Name (Vector)
diphosphoinositol pentakisphosphate kinase 2
Gene Symbol
PPIP5K2
HGNC ID
HGNC:29035
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3669
ORF Size (bp)
3669 bp
Protein Name (eCommerce)
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2
RefSeq ID
NM_015216
RefSeq Synonyms
NM_015216, NM_001345878, NM_001345877, NM_001345876, NM_001345875, NM_001345874, NM_001345873, NM_001345872, NM_001345871, NM_001281471, NM_001276277, BC024591,
Research Areas
Kinase/Phosphatase,Metabolism/Metabolic Process,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,metabolism
Species
human
Target Sentence
PPIP5K2 is a bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. PPPIP5K2 phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, PPIP5K2 phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O43314].
UniGene ID
Hs.212046
UniProt ID (eCommerce)
O43314

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.