human GNPTAB Adenovirus

Name 
Ad-h-GNPTAB
Cat No 
ADV-210138
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human GNPTAB.

ADV-210138
Ad-h-GNPTAB

Ready-to-use Adenovirus expressing Human GNPTAB (N-acetylglucosamine-1-phosphate transferase alpha and beta subunits). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
GNPTA; ICD
Description (Vector)
GNPTAB encodes two of three subunit types of the membrane-bound enzyme N-acetylglucosamine-1-phosphotransferase, a heterohexameric complex composed of two alpha, two beta, and two gamma subunits. The encoded protein is proteolytically cleaved at the Lys928-Asp929 bond to yield mature alpha and beta polypeptides while the gamma subunits are the product of a distinct gene (GeneID 84572). In the Golgi apparatus, the heterohexameric complex catalyzes the first step in the synthesis of mannose 6-phosphate recognition markers on certain oligosaccharides of newly synthesized lysosomal enzymes. These recognition markers are essential for appropriate trafficking of lysosomal enzymes. Mutations in this gene have been associated with both mucolipidosis II and mucolipidosis IIIA.
Gene ID
79158
Gene Name (Vector)
N-acetylglucosamine-1-phosphate transferase alpha and beta subunits
Gene Symbol
GNPTAB
HGNC ID
HGNC:29670
ORF Size (aa)
3771
ORF Size (bp)
3771 bp
RefSeq ID
NM_024312
RefSeq Synonyms
NM_024312, BC131787, BC002779,
Species
human
UniGene ID
Hs.46850

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.