human GLA Adenovirus

Name
Ad-h-GLA

Cat No
ADV-209956

Availability
4-5 weeks

This is an Adenovirus expressing Human GLA.

ADV-209956

Ad-h-GLA

Ready-to-use Adenovirus expressing Human GLA (galactosidase alpha). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

GALA

Description (Vector)

GLA encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties.

Gene ID

2717

Gene Name (Vector)

galactosidase alpha

Gene Symbol

GLA

HGNC ID

HGNC:4296

ORF Size (aa)

1290

ORF Size (bp)

1290 bp

RefSeq ID

NM_000169

RefSeq Synonyms

NM_000169, BC002689,

Species

human

UniGene ID

Hs.69089

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.