human GCSH Adenovirus
This is an Adenovirus expressing Human GCSH.
ADV-209763
Ad-h-GCSH
Ready-to-use Adenovirus expressing Human GCSH (glycine cleavage system protein H). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GCE; NKH
Description (Vector)
Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the H protein, which transfers the methylamine group of glycine from the P protein to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH). Two transcript variants, one protein-coding and the other probably not protein-coding,have been found for this gene. Also, several transcribed and non-transcribed pseudogenes of this gene exist throughout the genome.
Gene ID
2653
Gene Name (Vector)
glycine cleavage system protein H
Gene Symbol
GCSH
HGNC ID
HGNC:4208
ORF Size (aa)
522
ORF Size (bp)
522 bp
RefSeq ID
NM_004483
RefSeq Synonyms
NM_004483, BC020922, BC009065, BC000790,
Species
human
UniGene ID
Hs.546256
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.