human FGD4 Adenovirus

Name
Ad-h-FGD4

Cat No
ADV-208937

Availability
4-5 weeks

This is an Adenovirus expressing Human FGD4.

ADV-208937

Ad-h-FGD4

Ready-to-use Adenovirus expressing Human FGD4 (FYVE, RhoGEF and PH domain containing 4). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Vector Designer

Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

CMT4H; FRABP; ZFYVE6

Description (Vector)

FGD4 encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system.

Gene ID

121512

Gene Name (Vector)

FYVE, RhoGEF and PH domain containing 4

Gene Symbol

FGD4

HGNC ID

HGNC:19125

ORF Size (aa)

1416

ORF Size (bp)

1416 bp

RefSeq ID

NM_139241

RefSeq Synonyms

NM_139241, NM_001330374, NM_001330373, NM_001304484, NM_001304483, NM_001304481, NM_001304480, BC045552,

Species

human

UniGene ID

Hs.117835

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.