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human ERCC6 Adenovirus

Name 
Ad-h-ERCC6
Cat No 
ADV-208063
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human ERCC6.

ADV-208063
Ad-h-ERCC6

Ready-to-use Adenovirus expressing Human ERCC6 (ERCC excision repair 6, chromatin remodeling factor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ARMD5; ATP-dependent helicase ERCC6; Chimeric CSB-PGBD3 protein; Chimeric ERCC6-PGBD3 protein; CKN2; Cockayne syndrome group B protein; cockayne syndrome protein CSB; COFS; COFS1; CSB; CSB-PGBD3; DNA excision repair protein ERCC-6; ERCC6-PGBD3 fusion protein; excision repair cross-complementation group 6; excision repair cross-complementing rodent repair deficiency, complementation group 6; POF11; RAD26; UVSS1
Description (eCommerce)
ERCC6, also known as Cockayne syndrome B protein, is involved in DNA repair in response to UV exposure. ERCC6 has been reported to display ATPase and helicase activity and functions as a transcriptional regulator. Mutations in ERCC6 are the cause of Cockayne syndrome type B (CSB), cerebro-oculo-facio-skeletal syndrome type 1 (COFS1), De Sanctis-Cacchione syndrome (DCS), age-related macular degeneration type 5 (ARMD5), and UV-sensitive syndrome (UVS).
Description (Vector)
ERCC6 encodes a DNA-binding protein that is important in transcription-coupled excision repair. The protein has ATP-stimulated ATPase activity; there are contradictory publications reporting presence or absence of helicase activity. The protein appears to interact with several transcription and excision repair proteins, and may promote complex formation at repair sites. Mutations in this gene result in Cockayne syndrome type B.
Gene ID
2074
Gene Name (eCommerce)
ERCC excision repair 6, chromatin remodeling factor
Gene Name (Vector)
ERCC excision repair 6, chromatin remodeling factor
Gene Symbol
ERCC6
HGNC ID
HGNC:3438
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4482
ORF Size (bp)
4482 bp
Protein Name (eCommerce)
DNA excision repair protein ERCC-6
RefSeq ID
NM_000124
RefSeq Synonyms
NM_001346440, NM_001277059, NM_001277058, NM_000124, BC127104,
Research Areas
Apoptosis,DNA Damage/Repair,Gene Expression,Helicase Activity,Neurobiology,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,transcription_translation,neurobiology
Species
human
Target Sentence
ERCC6, also known as Cockayne syndrome B protein, is involved in DNA repair in response to UV exposure. ERCC6 has been reported to display ATPase and helicase activity and functions as a transcriptional regulator. Mutations in ERCC6 are the cause of Cockayne syndrome type B (CSB), cerebro-oculo-facio-skeletal syndrome type 1 (COFS1), De Sanctis-Cacchione syndrome (DCS), age-related macular degeneration type 5 (ARMD5), and UV-sensitive syndrome (UVS).
UniGene ID
Hs.654449
UniProt ID (eCommerce)
Q03468

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.