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human EGLN3 Adenovirus

Name 
Ad-h-EGLN3
Cat No 
ADV-207665
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human EGLN3.

ADV-207665
Ad-h-EGLN3

Ready-to-use Adenovirus expressing Human EGLN3 (egl-9 family hypoxia inducible factor 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
egl nine homolog 3; egl nine-like protein 3 isoform; HIFP4H3; HIFPH3; HIF-PH3; HIF-prolyl hydroxylase 3; HPH-1; HPH-3; hypoxia-inducible factor prolyl hydroxylase 3; PHD3; prolyl hydroxylase domain-containing protein 3
Description (eCommerce)
PHD3 is one of 4 PHD (PHD1-4) enzymes that function as oxygen sensors and are responsible for the post-translational modification of HIF-1alpha, a component of a transcriptional complex involved in oxygen homeostasis. During normoxic levels, PHDs catalyze the hydroxylation of prolyl residues on HIF-1alpha and target it for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. The PHD isoforms appear to function in a non-redundant manner and may differ in their expression patterns and their catalytic selectivity.
Gene ID
112399
Gene Name (eCommerce)
egl-9 family hypoxia inducible factor 3
Gene Name (Vector)
egl-9 family hypoxia inducible factor 3
Gene Symbol
EGLN3
HGNC ID
HGNC:14661
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
360
ORF Size (bp)
360 bp
Protein Name (eCommerce)
Egl nine homolog 3
RefSeq ID
NM_022073
RefSeq Synonyms
NM_022073, NM_001308103, BC111057, BC105939, BC105938, BC102030, BC064924, BC010992,
Research Areas
Apoptosis,Cancer,DNA Damage/Repair,HIF-1 Signaling,Hypoxia,Kidney Cancer,Neurobiology,Signal Transduction,Ubiquitination
Research Areas (Faceted)
cancer,cell_biology,genetics,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
PHD3 is one of 4 PHD (PHD1-4) enzymes that function as oxygen sensors and are responsible for the post-translational modification of HIF-1alpha, a component of a transcriptional complex involved in oxygen homeostasis. During normoxic levels, PHDs catalyze the hydroxylation of prolyl residues on HIF-1alpha and target it for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. The PHD isoforms appear to function in a non-redundant manner and may differ in their expression patterns and their catalytic selectivity.
UniGene ID
Hs.135507
UniProt ID (eCommerce)
Q9H6Z9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.