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human DOCK1 Adenovirus

Name 
Ad-h-DOCK1
Cat No 
ADV-207223
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human DOCK1.

ADV-207223
Ad-h-DOCK1

Ready-to-use Adenovirus expressing Human DOCK1 (dedicator of cytokinesis 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
180 kDa protein downstream of CRK; ced5; dedicator of cytokinesis protein 1; DOCK180; DOwnstream of CrK
Description (eCommerce)
DOCK80 is a non-conventional Rho-guanine nucleotide exchange factor (Rho-GEF) that functions to activate the small GTPases Rac and Cdc42. It is a member of the CZH (CDM-zizimin homology) family of proteins that contain two highly conserved domains, CZH1 and CZH2. Dock180 functions to activate Rac and regulate cell adhesion, cell spreading, migration and phagocytosis.
Description (Vector)
DOCK1 product binds to the SH3 domain of CRK protein. It may regulate cell surface extension and may have a role in the cell surface extension of an engulfing cell around a dying cell during apoptosis.
Gene ID
1793
Gene Name (eCommerce)
dedicator of cytokinesis 1
Gene Name (Vector)
dedicator of cytokinesis 1
Gene Symbol
DOCK1
HGNC ID
HGNC:2987
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5598
ORF Size (bp)
5598 bp
Protein Name (eCommerce)
Dedicator of cytokinesis protein 1
RefSeq ID
NM_001380
RefSeq Synonyms
NM_001380, NM_001290223, BC146857,
Research Areas
Apoptosis,Axon Guidance,Cancer,Cytoskeleton,EGFR Signaling,HGF Signaling,Immunology,Innate Immunity,Neurobiology,Prostate Cancer,Signal Transduction
Research Areas (Faceted)
cancer,cell_biology,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
DOCK80 is a non-conventional Rho-guanine nucleotide exchange factor (Rho-GEF) that functions to activate the small GTPases Rac and Cdc42. It is a member of the CZH (CDM-zizimin homology) family of proteins that contain two highly conserved domains, CZH1 and CZH2. Dock180 functions to activate Rac and regulate cell adhesion, cell spreading, migration and phagocytosis.
UniGene ID
Hs.645702
UniProt ID (eCommerce)
Q14185

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.