human DHCR24 Adenovirus

Name 
Ad-h-DHCR24
Cat No 
ADV-206930
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human DHCR24.

ADV-206930
Ad-h-DHCR24

Ready-to-use Adenovirus expressing Human DHCR24 (24-dehydrocholesterol reductase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
DCE; Nbla03646; seladin-1; SELADIN1
Description (Vector)
DHCR24 encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
Gene ID
1718
Gene Name (Vector)
24-dehydrocholesterol reductase
Gene Symbol
DHCR24
HGNC ID
HGNC:2859
ORF Size (aa)
1551
ORF Size (bp)
1551 bp
RefSeq ID
NM_014762
RefSeq Synonyms
NM_014762, BC011669, BC004375,
Species
human
UniGene ID
Hs.498727

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.