human COIL Adenovirus

Name 
Ad-h-COIL
Cat No 
ADV-205676
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human AUNIP.

ADV-205676
Ad-h-COIL

Ready-to-use Adenovirus expressing Human COIL (coilin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CLN80; coilin; coilin p80; p80; p80-coilin
Description (eCommerce)
Coilin is a component of the nuclear coiled bodies (CBS) which are involved in the function or assembly/disassembly of nucleoplasmic snRNPs. During mitosis, CBS disassemble, coinciding with a mitotic-specific phosphorylation of p80 coilin [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q6PJP8].
Description (Vector)
COIL is an integral component of Cajal bodies (also called coiled bodies). Cajal bodies are nuclear suborganelles of varying number and composition that are involved in the post-transcriptional modification of small nuclear and small nucleolar RNAs. The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. Differential methylation and phosphorylation of coilin likely influences its localization among nuclear bodies and the composition and assembly of Cajal bodies. This gene has pseudogenes on chromosome 4 and chromosome 14.
Gene ID
8161
Gene Name (eCommerce)
coilin
Gene Name (Vector)
coilin
Gene Symbol
COIL
HGNC ID
HGNC:2184
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1731
ORF Size (bp)
1731 bp
Protein Name (eCommerce)
Coilin
RefSeq ID
NM_004645
RefSeq Synonyms
NM_004645, BC010385,
Research Areas
Immunology,RNA Processing
Research Areas (Faceted)
cell_biology,genetics,immunology,transcription_translation
Species
human
Target Sentence
Coilin is a component of the nuclear coiled bodies (CBS) which are involved in the function or assembly/disassembly of nucleoplasmic snRNPs. During mitosis, CBS disassemble, coinciding with a mitotic-specific phosphorylation of p80 coilin [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q6PJP8].
UniGene ID
Hs.532795
UniProt ID (eCommerce)
P38432

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.