human COCH Adenovirus
This is an Adenovirus expressing Human COCH.
ADV-205663
Ad-h-COCH
Ready-to-use Adenovirus expressing Human COCH (cochlin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
COCH-5B2; COCH5B2; DFNA9
Description (Vector)
COCH is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated.
Gene ID
1690
Gene Name (Vector)
cochlin
Gene Symbol
COCH
HGNC ID
HGNC:2180
ORF Size (aa)
1485
ORF Size (bp)
1485 bp
RefSeq ID
NM_004086
RefSeq Synonyms
NM_004086, NM_001135058, BC007230,
Species
human
UniGene ID
Hs.21016
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.