human CMA1 Adenovirus
This is an Adenovirus expressing Human CMA1.
ADV-205534
Ad-h-CMA1
Ready-to-use Adenovirus expressing Human CMA1 (chymase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
chymase; CYH; MCT1
Description (Vector)
CMA1 product is a chymotryptic serine proteinase that belongs to the peptidase family S1. It is expressed in mast cells and thought to function in the degradation of the extracellular matrix, the regulation of submucosal gland secretion, and the generation of vasoactive peptides. In the heart and blood vessels, this protein, rather than angiotensin converting enzyme, is largely responsible for converting angiotensin I to the vasoactive peptide angiotensin II. Angiotensin II has been implicated in blood pressure control and in the pathogenesis of hypertension, cardiac hypertrophy, and heart failure. Thus, this gene product is a target for cardiovascular disease therapies. CMA1 maps to 14q11.2 in a cluster of genes encoding other proteases.
Gene ID
1215
Gene Name (Vector)
chymase 1
Gene Symbol
CMA1
HGNC ID
HGNC:2097
ORF Size (aa)
411
ORF Size (bp)
411 bp
RefSeq ID
NM_001836
RefSeq Synonyms
NM_001836, NM_001308083, BC103975, BC103974, BC069490, BC069370, BC069110,
Species
human
UniGene ID
Hs.135626
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.