human CLCN3 Adenovirus

Name
Ad-h-CLCN3

Cat No
ADV-205350

Availability
4-5 weeks

This is an Adenovirus expressing Human CLCN3.

ADV-205350

Ad-h-CLCN3

Ready-to-use Adenovirus expressing Human CLCN3 (chloride voltage-gated channel 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

ClC-3; CLC3

Description (Vector)

CLCN3 encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Gene ID

1182

Gene Name (Vector)

chloride voltage-gated channel 3

Gene Symbol

CLCN3

HGNC ID

HGNC:2021

ORF Size (aa)

2454

ORF Size (bp)

2454 bp

RefSeq ID

NM_001829

RefSeq Synonyms

NM_173872, NM_001829, NM_001243374, NM_001243372, BC146697, BC136510,

Species

human

UniGene ID

Hs.481186

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.