human CLCF1 Adenovirus
This is an Adenovirus expressing Human BORCS6.
ADV-205342
Ad-h-CLCF1
Ready-to-use Adenovirus expressing Human CLCF1 (cardiotrophin-like cytokine factor 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BSF-3; BSF3; CISS2; CLC; NNT-1; NNT1; NR6
Description (Vector)
CLCF1 is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Gene ID
23529
Gene Name (Vector)
cardiotrophin-like cytokine factor 1
Gene Symbol
CLCF1
HGNC ID
HGNC:17412
ORF Size (aa)
678
ORF Size (bp)
678 bp
RefSeq ID
NM_013246
RefSeq Synonyms
NM_013246, NM_001166212, BC066231, BC066230, BC066229, BC012939,
Species
human
UniGene ID
Hs.502977
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.