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human CHN2 Adenovirus

Name 
Ad-h-CHN2
Cat No 
ADV-205177
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human CHN2.

ADV-205177
Ad-h-CHN2

Ready-to-use Adenovirus expressing Human CHN2 (chimerin 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ARHGAP3; BCH; CHN2-3; RHOGAP3
Description (Vector)
CHN2 is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Gene ID
1124
Gene Name (Vector)
chimerin 2
Gene Symbol
CHN2
HGNC ID
HGNC:1944
ORF Size (aa)
1407
ORF Size (bp)
1407 bp
RefSeq ID
NM_004067
RefSeq Synonyms
NM_004067, NM_001293081, NM_001293080, NM_001293079, NM_001293078, NM_001293077, NM_001293076, NM_001293075, NM_001293073, NM_001293072, NM_001293071, NM_001293070, NM_001293069, NM_001039936, BC112155,
Species
human
UniGene ID
Hs.710429

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.