human CCM2 Adenovirus

Name 
Ad-h-CCM2
Cat No 
ADV-204469
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human CCM2.

ADV-204469
Ad-h-CCM2

Ready-to-use Adenovirus expressing Human CCM2 (CCM2 scaffolding protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
C7orf22; OSM; PP10187
Description (Vector)
CCM2 encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
83605
Gene Name (Vector)
CCM2 scaffolding protein
Gene Symbol
CCM2
HGNC ID
HGNC:21708
ORF Size (aa)
1335
ORF Size (bp)
1335 bp
RefSeq ID
NM_031443
RefSeq Synonyms
NM_031443, NM_001167935, NM_001167934, NM_001029835, BC063663, BC016832, BC008859, BC004903,
Species
human
UniGene ID
Hs.148272

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.