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human CAND1 Adenovirus

Name 
Ad-h-CAND1
Cat No 
ADV-204025
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human CAND1.

ADV-204025
Ad-h-CAND1

Ready-to-use Adenovirus expressing Human CAND1 (cullin associated and neddylation dissociated 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Cullin-associated and neddylation-dissociated protein 1; cullin-associated NEDD8-dissociated protein 1; p120 CAND1; TBP-interacting protein 120A; TBP-interacting protein of 120 kDa A; TIP120; TIP120A
Description (eCommerce)
Cullin-associated NEDD8-dissociated protein 1 (CAND1) is a regulatory protein that interferes with the assembly of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex and thereby down-regulates ubiquitination of target proteins. CAND1 prevents neddylation of CUL1 by physically blocking access to the neddylation site and disrupts interactions between CUL1 and SKP1A and between CUL1 and F-box proteins. CAND1 also binds TATA binding protein and enhances transcription from various promoters [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q86VP6].
Gene ID
55832
Gene Name (eCommerce)
cullin associated and neddylation dissociated 1
Gene Name (Vector)
cullin associated and neddylation dissociated 1
Gene Symbol
CAND1
HGNC ID
HGNC:30688
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3693
ORF Size (bp)
3693 bp
Protein Name (eCommerce)
Cullin-associated NEDD8-dissociated protein 1
RefSeq ID
NM_018448
RefSeq Synonyms
NM_018448, NM_001329676, NM_001329675, NM_001329674, BC050341,
Research Areas
Immunology,Transcription Factor/Regulator,Ubiquitination
Research Areas (Faceted)
cell_biology,immunology,transcription_translation
Species
human
Target Sentence
Cullin-associated NEDD8-dissociated protein 1 (CAND1) is a regulatory protein that interferes with the assembly of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex and thereby down-regulates ubiquitination of target proteins. CAND1 prevents neddylation of CUL1 by physically blocking access to the neddylation site and disrupts interactions between CUL1 and SKP1A and between CUL1 and F-box proteins. CAND1 also binds TATA binding protein and enhances transcription from various promoters [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q86VP6].
UniGene ID
Hs.546407
UniProt ID (eCommerce)
Q86VP6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.