human BUB1 Adenovirus

Name 
Ad-h-BUB1
Cat No 
ADV-202355
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human ARFGEF1.

ADV-202355
Ad-h-BUB1

Ready-to-use Adenovirus expressing Human BUB1 (BUB1 mitotic checkpoint serine/threonine kinase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
BUB1 budding uninhibited by benzimidazoles 1 homolog; BUB1A; BUB1L; budding uninhibited by benzimidazoles 1 homolog; hBUB1; mitotic checkpoint serine/threonine-protein kinase BUB1; mitotic spindle checkpoint kinase; putative serine/threonine-protein kinase
Description (eCommerce)
Bub1 is cell cycle checkpoint kinase and component of the spindle checkpoint machinery. Bub1 and other spindle checkpoint proteins ensure that segregation does not proceed until all replicated chromatids are associated with a functional bipolar spindle. Bub1 functions to target Bub1-related protein (BubR1), Mad2, and polo-like kinase to kinetochores. It also functions to phosphorylate Cdc20 and inhibit ubiquitination of Pds1/securin by the anaphase-promoting complex (APC).
Description (Vector)
BUB1 encodes a kinase involved in spindle checkpoint function. The kinase functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint. Mutations in this gene have been associated with aneuploidy and several forms of cancer.
Gene ID
699
Gene Name (eCommerce)
BUB1 mitotic checkpoint serine/threonine kinase
Gene Name (Vector)
BUB1 mitotic checkpoint serine/threonine kinase
Gene Symbol
BUB1
HGNC ID
HGNC:1148
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3258
ORF Size (bp)
3258 bp
Protein Name (eCommerce)
Mitotic checkpoint serine/threonine-protein kinase BUB1
RefSeq ID
NM_004336
RefSeq Synonyms
NM_004336, NM_001278617, NM_001278616, BC028201,
Research Areas
Apoptosis,Cell Cycle,Cell Division,Host-Virus Interactions,Kinase/Phosphatase,Meiosis,PLK1 Signaling,Signal Transduction
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,infectious_disease,signal_transduction
Species
human
Target Sentence
Bub1 is cell cycle checkpoint kinase and component of the spindle checkpoint machinery. Bub1 and other spindle checkpoint proteins ensure that segregation does not proceed until all replicated chromatids are associated with a functional bipolar spindle. Bub1 functions to target Bub1-related protein (BubR1), Mad2, and polo-like kinase to kinetochores. It also functions to phosphorylate Cdc20 and inhibit ubiquitination of Pds1/securin by the anaphase-promoting complex (APC).
UniGene ID
Hs.469649
UniProt ID (eCommerce)
O43683

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.