human ARAP1 Adenovirus

Name 
Ad-h-ARAP1
Cat No 
ADV-201251
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human ARAP1.

ADV-201251
Ad-h-ARAP1

Ready-to-use Adenovirus expressing Human ARAP1 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1; ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containing protein 1; centaurin-delta-2; CENTD2; cnt-d2
Description (eCommerce)
CENTD2/ARAP1 is an adapter protein that functions as an Arf 1 and Rho GTPase-activation protein. CENTD2/ARAP1 associates with the Golgi and appears to play a role in cytoskeleton remodeling as well as membrane receptor recycling and trafficking.
Description (Vector)
ARAP1 contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
116985
Gene Name (eCommerce)
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Gene Name (Vector)
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Gene Symbol
ARAP1
HGNC ID
HGNC:16925
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3402
ORF Size (bp)
3402 bp
Protein Name (eCommerce)
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
RefSeq ID
NM_015242
RefSeq Synonyms
NM_015242, NM_001135190, NM_001040118, BC144562, BC140792,
Research Areas
Cytoskeleton,EGFR Signaling,Golgi Apparatus,Immunology,PDGF Signaling,RAC1 Signaling,Rho Signaling,Signal Transduction,T-cell Receptor Signaling,Zinc-finger
Research Areas (Faceted)
cell_biology,immunology,signal_transduction
Species
human
Target Sentence
CENTD2/ARAP1 is an adapter protein that functions as an Arf 1 and Rho GTPase-activation protein. CENTD2/ARAP1 associates with the Golgi and appears to play a role in cytoskeleton remodeling as well as membrane receptor recycling and trafficking.
UniGene ID
Hs.503165
UniProt ID (eCommerce)
Q96P48

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.