human APOC1 Adenovirus

Name 
Ad-h-APOC1
Cat No 
ADV-201190
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human APOC1.

ADV-201190
Ad-h-APOC1

Ready-to-use Adenovirus expressing Human APOC1 (apolipoprotein C1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Apo-CI; ApoC-I; apo-CIB; apoC-IB; Apolipoprotein C1; apolipoprotein C-I
Description (eCommerce)
ApoCI contains 57 amino acid residues and the m.w. is 6.6 kDa (Jackson et al., 1974). ApoCI has been found to activate LCAT (Liu and Subbaiah 1993). Apo CI is an inhibitor of lipoprotein binding to the LDL receptor, LDL receptor-related protein, and VLDL receptor. Apo CI is also an inhibitor of the plasma cholesteryl ester transfer protein and of fatty acid uptake into tissues (Shachter, 2001). This inhibition role can potentially regulate several lipase enzymes. (Poensgen, 1990, Conde-Knape et al., 2002; Berbee et al., 2005)
Description (Vector)
APOC1 is a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
Gene ID
341
Gene Name (eCommerce)
apolipoprotein C1
Gene Name (Vector)
apolipoprotein C1
Gene Symbol
APOC1
HGNC ID
HGNC:607
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
252
ORF Size (bp)
252 bp
Protein Name (eCommerce)
Apolipoprotein C-I
RefSeq ID
NM_001645
RefSeq Synonyms
NM_001645, NM_001321066, NM_001321065, BC055093, BC009698,
Research Areas
Cardiovascular
Research Areas (Faceted)
cardiovascular
Species
human
Target Sentence
ApoCI contains 57 amino acid residues and the m.w. is 6.6 kDa (Jackson et al., 1974). ApoCI has been found to activate LCAT (Liu and Subbaiah 1993). Apo CI is an inhibitor of lipoprotein binding to the LDL receptor, LDL receptor-related protein, and VLDL receptor. Apo CI is also an inhibitor of the plasma cholesteryl ester transfer protein and of fatty acid uptake into tissues (Shachter, 2001). This inhibition role can potentially regulate several lipase enzymes. (Poensgen, 1990, Conde-Knape et al., 2002; Berbee et al., 2005)
UniGene ID
Hs.110675
UniProt ID (eCommerce)
P02654

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.