human API5 Adenovirus

Name 
Ad-h-API5
Cat No 
ADV-201149
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human AHCYL1.

ADV-201149
Ad-h-API5

Ready-to-use Adenovirus expressing Human API5 (apoptosis inhibitor 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
AAC11; AAC-11; antiapoptosis clone 11 protein; API-5; apoptosis inhibitor 5; cell migration-inducing gene 8 protein; Fibroblast growth factor 2-interacting factor; fibroblast growth factor 2-interacting factor 2; FIF; migration-inducing protein MIG8; Protein XAGL
Description (eCommerce)
API5 (apoptosis inhibitor 5) is an antiapoptotic factor that may have a role in protein assembly. API5 negatively regulates ACIN1. By binding to ACIN1, API5 suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. API5 is also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.
Description (Vector)
API5 encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID
8539
Gene Name (eCommerce)
apoptosis inhibitor 5
Gene Name (Vector)
apoptosis inhibitor 5
Gene Symbol
API5
HGNC ID
HGNC:594
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1515
ORF Size (bp)
1515 bp
Protein Name (eCommerce)
Apoptosis inhibitor 5
RefSeq ID
NM_006595
RefSeq Synonyms
NM_006595, NM_001243747, NM_001142931, NM_001142930, BC017709,
Research Areas
Apoptosis,FGF Signaling,Gene Expression,RNA Processing,Signal Transduction,Spliceosome
Research Areas (Faceted)
cell_biology,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
API5 (apoptosis inhibitor 5) is an antiapoptotic factor that may have a role in protein assembly. API5 negatively regulates ACIN1. By binding to ACIN1, API5 suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. API5 is also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.
UniGene ID
Hs.435771
UniProt ID (eCommerce)
Q9BZZ5

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.