human AFF4 Adenovirus

Name 
Ad-h-AFF4
Cat No 
ADV-200534
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human ACTG1.

ADV-200534
Ad-h-AFF4

Ready-to-use Adenovirus expressing Human AFF4 (AF4/FMR2 family member 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
AF4/FMR2 family member 4; AF5Q31; ALL1-fused gene from chromosome 5q31 protein; CHOPS; major CDK9 elongation factor-associated protein; MCEF; Protein AF-5q31
Description (eCommerce)
Major CDK9 elongation factor-associated protein (MCEF) is also known as AFF4 AF4/FMR2 family member 4. This family of proteins includes the AF4 proto-oncogene and FMR2 (fragile X E mental retardation syndrome) nuclear proteins. MCEF is a component of the cyclin-dependent kinase pair (CDK9/cyclin T1) complex. A chromosomal aberration involving AFF4 is found in acute lymphoblastic leukemia (ALL).
Description (Vector)
AFF4 belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5;11)(q31;q31q23).
Gene ID
27125
Gene Name (eCommerce)
AF4/FMR2 family member 4
Gene Name (Vector)
AF4/FMR2 family member 4
Gene Symbol
AFF4
HGNC ID
HGNC:17869
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3492
ORF Size (bp)
3492 bp
Protein Name (eCommerce)
AF4/FMR2 family member 4
RefSeq ID
NM_014423
RefSeq Synonyms
NM_014423, BC137226, BC063007,
Research Areas
Cancer,Mitochondrion,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,transcription_translation
Species
human
Target Sentence
Major CDK9 elongation factor-associated protein (MCEF) is also known as AFF4 AF4/FMR2 family member 4. This family of proteins includes the AF4 proto-oncogene and FMR2 (fragile X E mental retardation syndrome) nuclear proteins. MCEF is a component of the cyclin-dependent kinase pair (CDK9/cyclin T1) complex. A chromosomal aberration involving AFF4 is found in acute lymphoblastic leukemia (ALL).
UniGene ID
Hs.664840
UniProt ID (eCommerce)
Q9UHB7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.