human ACE2 Adenovirus

Name 
Ad-h-ACE2
Cat No 
ADV-200183
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human ACE2.

ADV-200183
Ad-h-ACE2

Ready-to-use Adenovirus expressing Human ACE2 (angiotensin I converting enzyme 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ACEH; ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin-converting enzyme 2; angiotensin-converting enzyme homolog; metalloprotease MPROT15; peptidyl-dipeptidase A
Description (eCommerce)
ACE2 acts as a receptor for human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63. ACE2 is also an essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. (Uniprot)
Description (Vector)
ACE2 belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63.
Gene ID
59272
Gene Name (eCommerce)
angiotensin I converting enzyme 2
Gene Name (Vector)
angiotensin I converting enzyme 2
Gene Symbol
ACE2
HGNC ID
HGNC:13557
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2418
ORF Size (bp)
2418 bp
Protein Name (eCommerce)
Angiotensin-converting enzyme 2
RefSeq ID
NM_021804
RefSeq Synonyms
NM_021804, BC048094, BC039902,
Research Areas
Cardiovascular,Host-Virus Interactions,Immunology,Response to Virus,Signal Transduction
Research Areas (Faceted)
cardiovascular,signal_transduction,infectious_disease,immunology,infectious_disease
Species
human
Target Sentence
ACE2 acts as a receptor for human coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus NL63/HCoV-NL63. ACE2 is also an essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume, systemic vascular resistance, and thus cardiovascular homeostasis. (Uniprot)
UniGene ID
Hs.178098
UniProt ID (eCommerce)
Q9BYF1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.