human ABCA7 Adenovirus

Name 
Ad-h-ABCA7
Cat No 
ADV-200053
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Human ABCA7.

ADV-200053
Ad-h-ABCA7

Ready-to-use Adenovirus expressing Human ABCA7 (ATP binding cassette subfamily A member 7). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ABCA-SSN; ABCX; AD9; ATP-binding cassette sub-family A member 7; ATP-binding cassette, sub-family A (ABC1), member 7; autoantigen SS-N; macrophage ABC transporter
Description (eCommerce)
ATP-binding cassette sub-family A member 7 (ABCA7) plays a role in phagocytosis by macrophages of apoptotic cells. It binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. ABCA7 may also mediate cholesterol efflux and may regulate cellular ceramide homeostasis during keratinocytes differentiation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8IZY2].
Description (Vector)
ABCA7 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system.
Gene ID
10347
Gene Name (eCommerce)
ATP binding cassette subfamily A member 7
Gene Name (Vector)
ATP binding cassette subfamily A member 7
Gene Symbol
ABCA7
HGNC ID
HGNC:37
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
6441
ORF Size (bp)
6441 bp
Protein Name (eCommerce)
ATP-binding cassette sub-family A member 7
RefSeq ID
NM_019112
RefSeq Synonyms
NM_019112, BC172426,
Research Areas
Golgi Apparatus,Metabolism/Metabolic Process,Transport
Research Areas (Faceted)
cell_biology,metabolism
Species
human
Target Sentence
ATP-binding cassette sub-family A member 7 (ABCA7) plays a role in phagocytosis by macrophages of apoptotic cells. It binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. ABCA7 may also mediate cholesterol efflux and may regulate cellular ceramide homeostasis during keratinocytes differentiation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8IZY2].
UniGene ID
Hs.134514
UniProt ID (eCommerce)
Q8IZY2

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.