rat DNAJB6 Over-expression AAV
This is an AAV expressing Rat Dnajb6.
AAV-290984
AAV-r-DNAJB6
Ready-to-use AAV expressing Rat Dnajb6 (DnaJ heat shock protein family (Hsp40) member B6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity.
Gene ID
362293
Gene Name (Vector)
DnaJ heat shock protein family (Hsp40) member B6
Gene Symbol
Dnajb6
ORF Size (aa)
1074
ORF Size (bp)
1074 bp
RefSeq ID
NM_001013209
RefSeq Synonyms
NM_001013209, BC078908,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.