rat PSAP Over-expression AAV
This is an AAV expressing Rat Psap.
AAV-290370
AAV-r-PSAP
Ready-to-use AAV expressing Rat Psap (prosaposin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
SGP-1; SGP1A
Description (Vector)
The lysosomal degradation of sphingolipids takes place by the sequential action of specific hydrolases. Some of these enzymes require specific low-molecular mass, non-enzymic proteins: the sphingolipids activator proteins (coproteins)|Function: Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate|Function: Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases|Function: Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12).
Gene ID
25524
Gene Name (Vector)
prosaposin
Gene Symbol
Psap
ORF Size (aa)
1662
ORF Size (bp)
1662 bp
RefSeq ID
NM_013013
RefSeq Synonyms
NM_013013, NM_001190238, NM_001190237, NM_001190236, BC061759,
Species
rat
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.