mouse PAK3 Over-expression AAV

Name 
AAV-m-PAK3
Cat No 
AAV-280956
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Pak3.

AAV-280956
AAV-m-PAK3

Ready-to-use AAV expressing Mouse Pak3 (p21 protein (Cdc42/Rac)-activated kinase 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
PAK-3; Pak65alpha; Pak65beta; Stk4
Description (Vector)
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments.
Gene ID
18481
Gene Name (Vector)
p21 protein (Cdc42/Rac)-activated kinase 3
Gene Symbol
Pak3
ORF Size (aa)
1635
ORF Size (bp)
1635 bp
RefSeq ID
NM_008778
RefSeq Synonyms
NM_008778, NM_001195049, NM_001195048, NM_001195047, NM_001195046, BC053403,
Species
mouse
UniGene ID
Mm.40035

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.