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mouse MBD1 Over-expression AAV

Name 
AAV-m-MBD1
Cat No 
AAV-280878
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Mbd1.

AAV-280878
AAV-m-MBD1

Ready-to-use AAV expressing Mouse Mbd1 (methyl-CpG binding domain protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Cxxc3; PCM1
Description (Vector)
Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.
Gene ID
17190
Gene Name (Vector)
methyl-CpG binding domain protein 1
Gene Symbol
Mbd1
ORF Size (aa)
1767
ORF Size (bp)
1767 bp
RefSeq ID
NM_013594
RefSeq Synonyms
NM_013594, BC069837,
Species
mouse
UniGene ID
Mm.22522

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.