mouse MAPK7 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-280873
Availability:
3-5 weeks
Name:
AAV-m-MAPK7
This is an AAV expressing Mouse Mapk7.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Mouse
- Gene Symbol
- Mapk7
- Gene Name
- mitogen-activated protein kinase 7
- Gene ID
- 23939
- Gene Synonyms
- BMK-1; BMK1; ERK-5; ERK5; Erk5-T; PRKM7
- ORF Size
- 2271 bp
- RefSeq#
- BC100398
- Gene Description
- Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression.
- UniGene ID
- Mm.38172
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