mouse BRMS1 Over-expression AAV

Name
AAV-m-BRMS1

Cat No
AAV-278936

Availability
4-5 weeks

This is an AAV expressing Mouse Brms1.

AAV-278936

AAV-m-BRMS1

Ready-to-use AAV expressing Mouse Brms1 (breast cancer metastasis-suppressor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AV003220; AW554636

Description (Vector)

Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.

Gene ID

107392

Gene Name (Vector)

breast cancer metastasis-suppressor 1

Gene Symbol

Brms1

ORF Size (aa)

741

RefSeq ID

NM_134155

RefSeq Synonyms

NM_134155, BC016108, BC003485,

Species

mouse

UniGene ID

Mm.478009

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.