mouse WWP2 Over-expression AAV

Name 
AAV-m-WWP2
Cat No 
AAV-276354
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Wwp2.

AAV-276354
AAV-m-WWP2

Ready-to-use AAV expressing Mouse Wwp2 (WW domain containing E3 ubiquitin protein ligase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
1300010O06Rik; AA690238; AIP2; AW554328
Description (Vector)
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.
Gene ID
66894
Gene Name (Vector)
WW domain containing E3 ubiquitin protein ligase 2
Gene Symbol
Wwp2
ORF Size (aa)
2613
ORF Size (bp)
2613 bp
RefSeq ID
NM_025830
RefSeq Synonyms
NM_025830, BC048184, BC039921,
Species
mouse
UniGene ID
Mm.390058

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.