mouse ULBP1 Over-expression AAV

Name 
AAV-m-ULBP1
Cat No 
AAV-275615
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Ulbp1.

AAV-275615
AAV-m-ULBP1

Ready-to-use AAV expressing Mouse Ulbp1 (UL16 binding protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
A430108B07Rik; MULT1
Description (Vector)
Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
Gene ID
77777
Gene Name (Vector)
UL16 binding protein 1
Gene Symbol
Ulbp1
ORF Size (aa)
1005
ORF Size (bp)
1005 bp
RefSeq ID
NM_029975
RefSeq Synonyms
NM_029975, BC132072, BC132070,
Species
mouse
UniGene ID
Mm.442442

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.