mouse TSC1 Over-expression AAV

Name 
AAV-m-TSC1
Cat No 
AAV-275119
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Tsc1.

AAV-275119
AAV-m-TSC1

Ready-to-use AAV expressing Mouse Tsc1 (tuberous sclerosis 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Description (Vector)
In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.
Gene ID
64930
Gene Name (Vector)
tuberous sclerosis 1
Gene Symbol
Tsc1
ORF Size (aa)
3447
ORF Size (bp)
3447 bp
RefSeq ID
NM_022887
RefSeq Synonyms
NM_022887, NM_001289576, NM_001289575, BC052399,
Species
mouse
UniGene ID
Mm.224354

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.