mouse NR3C1 Over-expression AAV

Name 
AAV-m-NR3C1
Cat No 
AAV-266053
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Nr3c1.

AAV-266053
AAV-m-NR3C1

Ready-to-use AAV expressing Mouse Nr3c1 (nuclear receptor subfamily 3, group C, member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
glucocorticoid receptor; glucocorticoid receptor 1; glucocorticoid receptor subtype P; GR; Grl1; Grl-1
Description (eCommerce)
The glucocorticoid receptor (GR) functions as both a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues.
Description (Vector)
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation (By similarity).
Gene ID
14815
Gene Name (eCommerce)
nuclear receptor subfamily 3, group C, member 1
Gene Name (Vector)
nuclear receptor subfamily 3, group C, member 1
Gene Symbol
Nr3c1
NCBI Taxonomy ID (eCommerce)
10090.0
ORF Size (aa)
2352
ORF Size (bp)
2352 bp
Protein Name (eCommerce)
Glucocorticoid receptor
RefSeq ID
NM_008173
RefSeq Synonyms
NM_008173, BC129913, BC129912,
Research Areas
Chromatin Remodeling,Signal Transduction
Research Areas (Faceted)
cell_biology,genetics,signal_transduction
Species
mouse
Target Sentence
The glucocorticoid receptor (GR) functions as both a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues.
UniGene ID
Mm.129481
UniProt ID (eCommerce)
P06537

Related Citations

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.