mouse NFKBIZ Over-expression AAV

Name 
AAV-m-NFKBIZ
Cat No 
AAV-265731
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Nfkbiz.

AAV-265731
AAV-m-NFKBIZ

Ready-to-use AAV expressing Mouse Nfkbiz (nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AA408868; INAP; Mail
Description (Vector)
Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Seems also to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. May promote apoptosis (By similarity).
Gene ID
80859
Gene Name (Vector)
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
Gene Symbol
Nfkbiz
ORF Size (aa)
2187
ORF Size (bp)
2187 bp
RefSeq ID
NM_030612
RefSeq Synonyms
NM_030612, NM_001159395, NM_001159394, BC058188,
Species
mouse
UniGene ID
Mm.247272

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.