mouse MBNL1 Over-expression AAV

Name 
AAV-m-MBNL1
Cat No 
AAV-264324
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Mbnl1.

AAV-264324
AAV-m-MBNL1

Ready-to-use AAV expressing Mouse Mbnl1 (muscleblind-like 1 (Drosophila)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Mbnl; mKIAA0428
Description (Vector)
Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues.
Gene ID
56758
Gene Name (Vector)
muscleblind-like 1 (Drosophila)
Gene Symbol
Mbnl1
ORF Size (aa)
750
RefSeq ID
NM_020007
RefSeq Synonyms
NM_020007, NM_001310514, NM_001253713, NM_001253711, NM_001253710, NM_001253709, NM_001253708, BC096600,
Species
mouse
UniGene ID
Mm.255723

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.