mouse ZNRF1 Over-expression AAV

Name 
AAV-m-ZNRF1
Cat No 
AAV-263353
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Znrf1.

AAV-263353
AAV-m-ZNRF1

Ready-to-use AAV expressing Mouse Znrf1 (zinc and ring finger 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
B830022L21Rik; nin283; Rnf42; Zrfp1
Description (Vector)
E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable).
Gene ID
170737
Gene Name (Vector)
zinc and ring finger 1
Gene Symbol
Znrf1
ORF Size (aa)
684
ORF Size (bp)
684 bp
RefSeq ID
NM_133206
RefSeq Synonyms
NM_133206, NM_001168623, NM_001168622, NM_001168621, BC086770, BC006765,
Species
mouse
UniGene ID
Mm.271578

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.