mouse IRF3 Over-expression AAV

Name 
AAV-m-IRF3
Cat No 
AAV-262368
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Mouse Irf3.

AAV-262368
AAV-m-IRF3

Ready-to-use AAV expressing Mouse Irf3 (interferon regulatory factor 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
C920001K05Rik; interferon regulatory factor 3; IRF-3
Description (eCommerce)
Interferon regulatory factor 3 (IRF3) is a member of the IRF family of transcription factors that plays a critical role in immune cell function and development. IRF3 mediates interferon-stimulated response element (ISRE) promoter activation and functions as a molecular switch for antiviral activity.
Description (Vector)
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
Gene ID
54131
Gene Name (eCommerce)
interferon regulatory factor 3
Gene Name (Vector)
interferon regulatory factor 3
Gene Symbol
Irf3
NCBI Taxonomy ID (eCommerce)
10090.0
ORF Size (aa)
1260
ORF Size (bp)
1260 bp
Protein Name (eCommerce)
Interferon regulatory factor 3
RefSeq ID
NM_016849
RefSeq Synonyms
NM_016849, BC050882,
Research Areas
Apoptosis,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology
Species
mouse
Target Sentence
Interferon regulatory factor 3 (IRF3) is a member of the IRF family of transcription factors that plays a critical role in immune cell function and development. IRF3 mediates interferon-stimulated response element (ISRE) promoter activation and functions as a molecular switch for antiviral activity.
UniGene ID
Mm.3960
UniProt ID (eCommerce)
P70671

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.