mouse ERAP1 Over-expression AAV
This is an AAV expressing Mouse Erap1.
AAV-258618
AAV-m-ERAP1
Ready-to-use AAV expressing Mouse Erap1 (endoplasmic reticulum aminopeptidase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Arts1; ERAAP; PILSA; PILSAP
Description (Vector)
Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.
Gene ID
80898
Gene Name (Vector)
endoplasmic reticulum aminopeptidase 1
Gene Symbol
Erap1
ORF Size (aa)
2793
ORF Size (bp)
2793 bp
RefSeq ID
NM_030711
RefSeq Synonyms
NM_030711, BC046610,
Species
mouse
UniGene ID
Mm.83526
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.