mouse EPHB4 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-258582
Availability:
3-5 weeks
Name:
AAV-m-EPHB4
This is an AAV expressing Mouse Ephb4.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Mouse
- Gene Symbol
- Ephb4
- Gene Name
- Eph receptor B4
- Gene ID
- 13846
- Gene Synonyms
- AI042935; Htk; MDK2; Myk1; Tyro11
- ORF Size
- 2964 bp
- RefSeq#
- BC016505
- Gene Description
- Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.
- UniGene ID
- Mm.34533
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